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M94A2838.TXT
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1994-10-25
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Document 2838
DOCN M94A2838
TI The impact of pentoxifylline on quality of life.
DT 9412
AU Cohen CJ; Dezube BJ; Day JM; Andradas V; Gagnon S; Rieker PP; CRI/New
England, Boston, MA.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):213 (abstract no. PB0283). Unique
Identifier : AIDSLINE ICA10/94369737
AB OBJECTIVE: Pentoxifylline (PTX) has been shown to decrease tumor
necrosis factor (TNF) levels in AIDS patients. This study was designed
to test the effect of PTX on measures of quality of life (QOL) and
surrogate markers. METHODS: A randomized double-blind placebo controlled
design was used: patients were on PTX (400 mg. 3x/d) for 4 of 5 months;
placebo for one. Major eligibility was a Karnofsky score of > 40 and <
100%; all stages of HIV infection were eligible. QOL measures were the
profile of mood states (POMS) and a modified medical outcomes study
(MOS-HIV) scale. RESULTS: Fifty-nine people were randomized; 22 had
AIDS. At five months, 66% remained on study drug. There was significant
improvement in several aspects of QOL. The POMS showed less anger and
confusion (p = .05). In those without a prior AIDS diagnosis, the
findings were even stronger: there was improvement on the total POMS
mood score (p = .03), with less depression, anger (p = .01) and
confusion (p = .005). Three subscales on the MOS (social function,
cognitive function, feelings about health) showed similar benefit. No
significant changes were seen in safety lab markers. Adverse events
leading to drug withdrawal included headache (1), jitteriness (2) and GI
upset (3). CONCLUSION: The use of PTX may improve several specific
measures of quality of life. This benefit was even stronger in those
without AIDS.
DE Acquired Immunodeficiency Syndrome/DRUG THERAPY/PSYCHOLOGY *Affect
Anger Attitude to Health Cognition Confusion Depression
Double-Blind Method Human HIV Infections/*DRUG THERAPY/PSYCHOLOGY
Pentoxifylline/*THERAPEUTIC USE *Quality of Life Social Behavior
Treatment Outcome CLINICAL TRIAL MEETING ABSTRACT RANDOMIZED
CONTROLLED TRIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).